Darvocet A500 is made of napsylate and acetaminophen propoxyphene. Propoxyphene Napsylate, USP is a bitter-taste, smellless, white crystalline powder. This is water-soluble and methanol, chloroform and acetone soluble only slightly. The distinction between propoxyphene napsylate and propoxyphene chloride is that it allows more stable fluid dosage forms and tablet formulations.
For mild to moderate pain relief, Darvocet A500 are indicated. It can reduce the amount of fever as well.
Darvocet A500 is a powerful medication that relieves the pain and suppresses cough but is weaker than other medications, such as morphine, codine and hydrocodone. The exact mechanism of action is not known; however, opioid receptors in the brain may be stimulated. Darvocet A500 improves tolerance to pain and reduces malaise, but pain remains noticeable. Darvocet A500 causes sedation and respiratory depression in addition to pain relief. Acetaminophen is an anti-pyretic (fiever reducing) non-narcotic analgesic.
Darvocet A500 is designed for mild to moderate pain relief. Based on the severity and the patient reaction and patitis, the dosage should be changed individually.
Per 4 hours the normal dose of the pain is one tablet orally. Darvocet A500 has a daily dosage of 6 tablets a day. Do not exceed the daily maximum dose.
If necessary it would be necessary to carefully monitor patients received with propoxyphene and any inhibitors of CYP3A4 for a prolonged period of time and adjust dosing.
For older patients and in patients with hepatic or renal damage, a decreased average daily dose should be considered.
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