Barbiturates are nonselective depressants in the central nervous system which are mainly used in subhypnotic doses as sedative hypnotics as well as anticonvulsants. The barbiturates and their sodium salts under the Federal Controlled Substances Act are controlled.
When parenterally safe solutions are available the sodium salts of amobarbital, pentobarbital, phenobarbital and secobarbital. Barbiturates are replaced by pyrimidine derivatives, in which barbituric acid, a substance without central nervous system ( CNS) activity, constitutes the essential structure common to those drugs. The activity of CNS shall be achieved in a pyrimidine ring by replacing alkyl, alkenyl, or aryl groups.
A treatment for intravenous or intramuscular injections is NEMBUTAL Sodium (pentobarbital sodium injection). Every ml contains 50 mg of pentobarbital sodium, 40% of alcohol, 10% and water for injection in a propylene glycol tank. The pH of hydrochloric acid and/or sodium hydroxide is adjusted to approx. 9.5.
Dosage of barbiturates with complete awareness of their particular characteristics and prescribed administration rate must be individualised. Patient age, weight and disability are considered. Even when oral administration is not feasible or practicable can parenteral routes be used.
IM injection of barbiturate sodium salts should be made into a large muscle committed to it and 5 mL should not, because of possible tissue inflammation, be exceeded in one location. The vital signs of the patient should be tracked after IM administering a hypnotic dose. The normal adult dosage of NEMBUTAL sodium solution for single injection is 150 to 200 mg; the recommended dose ranges from 2 to 6 mg / kg as single injections not to exceed 100 mg as a single IM. The recommended pediatric injection.
Nembutal Sodium Solution (pentobarbital) No other drug and solution should be admixed with. IV injection is limited to the conditions where the patient is not able to take other routes because of unconsciousness, resistance or prompt action. Slow IV injection is important, while carefully monitoring patients during administration. This means maintaining blood pressure, respiration and cardiac function and recording of vital signs and the availability of artificial ventilation and resuscitation equipment. For pentobarbital sodium, the dose of IV injection does not exceed 50 mg / min.
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